COLIVELIN – 100 mg

COLIVELIN – 100 mg Product Information

Colivelin is a neuroprotective humanin family peptide with potent long-term capacity against Aβ deposition, neuronal apoptosis, and synaptic plasticity deficits in neurodegenerative disease.

Purchase 30 ml of bacteriostatic water separately. One 30ml bottle will be enough for multiple vials of peptides.

Colivelin is a brain penetrant neuroprotective peptide and a potent activator of STAT3 that suppresses neuronal death by activating STAT3 in vitro.

Colivelin exhibits long-term beneficial effects against neurotoxicity, Aβ deposition, neuronal apoptosis, and synaptic plasticity deficits in neurodegenerative disease. Colivelin has the potential for the treatment of Alzheimer’s disease and ischemic brain injury.

This hybrid peptide was synthesized to potentiate the neuroprotective effect of humanin (HN). Colivelin is composed of Activity-Dependent Neurotrophic Factor (ADNF) C-terminally fused to AGA-(C8R) HNG17, a potent HN derivative.

Colivelin completely suppresses cell death induced by overexpressed Familial Alzheimer’s disease (FAD)-causative genes and beta-amyloid. Colivelin administration decreased the neurological deficits and infarct lesion induced by brain ischemia.

Colivelin inhibited axonal damage and neuronal death in brain tissue, which was associated with elevated anti-apoptotic gene expression in ischemic neurons as well as increased axonal growth up until two-weeks post-stroke.

Moreover, Colivelin activated STAT3 signaling, which may partially contribute to its beneficial effect against neuronal death and axon growth. In conclusion, Colivelin induce anti-apoptotic genes up-regulation and activate JAK/STAT3 signaling after ischemic stroke, which may contribute to its effects of rescuing ischemic neuronal death and axonal remodelling.

. Label Information

Molecular Formula: C₁₁₉H₂₀₆N₃₂O₃₅

Sequence: H-Ser-Ala-Leu-Leu-Arg-Ser-Ile-Pro-Ala-Pro-Ala-Gly-Ala-Ser-Arg-Leu-Leu-Leu-Leu- Thr-Gly-Glu-Ile-Asp-Leu-Pro-OH

Molecular Weight: 2645.13 g/mol

CAS: 867021-83-8

Peptide Purity: >98%

Other details: No TFA Salt

Storage: Lyophilised peptide must be stored at -20°C and peptide solution at 4°C. Before mixing, keep between -18 and -20°C. Once reconstituted use within 20 days. Do not freeze once reconstituted.