P-21 – 50mg

P-21 – 50mg Product Information

P21 is developed from cerebrolysin, which is a peptide. It has a peptide purity of above 98,9 percent. Cerebrolysin is a peptide that has been used to help patients that have suffered from a stroke to recover some of their brain functions. In recent studies it has come to light that this drug can mitigate against an age-dependent decline in learning and memory. This has also been bundled with its neuroprotective qualities.

Research is still being carried out on the drug to shed light on other properties that it may have. For its known properties as of now, it’s a very attractive or rather a good candidate for the creation of precognitive medications to treat brain disorders, improve learning and memory, as well as to look to counter diseases such as the Alzheimer’s disease.

When it was administered in aged rats, it prevented the deficit in neurogenesis and increased expression of the neurotrophic factor of the brain. P21 can increase synaptophysin and synapsin I immunoreactivities. This means that this drug can restore synaptic deficits both in the cortex and hippocampus (hippocampus is the most vulnerable brain region for neurodegeneration).

This shows that it can enhance synaptic plasticity. Synaptophysin is a glycoprotein involved in vesicle trafficking machinery by regulating synaptic vesicle exocytosis. The glycoprotein is found in the presynaptic vesicle. When a vivo magnetic resonance spectroscopy is carried out it indicates that there were some dependent alterations in the hippocampal content of several metabolites.

Another observation that was seen in rats during the experiments was that the level of myoinositol concentration, which was increased in aged rats rather than in young rats, was reduced by P21. This led to conclusions that activating endogenous neuroprotective mechanisms can actually be a viable way of reducing or limiting cognitive ageing, Alzheimer’s, and other disorders that are neurodegenerative in nature.

P21 has been found to be effective in minimising cell death rates, basically apoptosis, enabling the drug to have insights into the treatment of ischemic stroke, post-operative trauma, and brain contusions.

Label Information

Ingredients:P-21 (with adamantyl group)

Formula: C₃₀H₅₄N₆O₅

Sequence: Ac-DGGL-adamantane-G-NH2

CAS: N/A

Peptide purity: Greater than 98.0%

Shipping Conditions: Ambient temperature only.

Storage: Lyophilised peptide must be stored at -20°C and peptide solution at 4°C. Before mixing, keep between -18 and -20°C. Use within 24 months. Once reconstituted use within 20 days. Do not freeze once reconstituted.