MOD GRF (1-29) Product Information

Peptide Growth hormone releasing factor (1-29) (abbreviated as GRF (1-29) or also known under the standardized name Sermorelin) is the “shortest fully functional fragment” of endogenous peptide hormone Growth-hormone-releasing hormone (GHRH; somatocrinin). More specifically, it is a fragment of the amino acid chain of GHRH, which is made up of its amino acids at positions 1-29.

The Mod GRF (1-29) peptide (also known as Modified GRF (1-29) or originally referred to as tetrasubstituted GRF (1-29)) is a modified version of the Growth hormone releasing factor (1-29). Specifically, this modification consists in replacing the amino acids located in the 2nd, 8th, 15th & 27th positions of the GRF (1-29) amino acid chain with amino acids more resistant to enzymatic cleavage: While the GRF 1-29 amino acid sequence is Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-NH₂ the MOD GRF 1-29 sequence is Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-NH_2. As a result of this modification, the initial half-life of GRF (1-29), which was less than 10 minutes, is extended to a longer half-life of MOD GRF (1-29), which is at least 30 minutes.

MOD GRF (1-29) dosage

In the scientific studies and clinical trials performed, the dosage used is often referred to as 1-3 mcg of MOD GRF (1-29) per 1 kg body weight, 1-3 times a day. For multiple doses, it is appropriate to distribute them equally over time throughout the day, to mimic the natural, pulsed release of natural growth hormone during the day. Administration of MOD GRF (1-29) alone may not significantly increase growth hormone secretion. Therefore, it is often combined with the administration of GHRPs such as Ipamorelin, GHRP-6, GHRP-2, or Hexarelin to ensure a significant increase in GH production, and at the same time, their combination works synergistically and greatly increases their effectiveness with each other.

Breief Overview of MOD GRF (1-29)

MOD GRF (1-29) (also called Modified GRF (1-29), tetrasubstituted GRF (1-29), or modified Growth hormone releasing factor (1-29)) is a modified version of Growth hormone releasing factor (1-29) and synthetic analog of endogenous peptide hormone GHRH. This modification consists in replacing the amino acids located in the 2nd, 8th, 15th & 27th positions of the GRF (1-29) amino acid chain with amino acids more resistant to enzymatic cleavage. As a result of this modification, the half-life is extended to 30 minutes. MOD GRF (1-29) mimics the action of natural endogenous Growth hormone-releasing hormone, in the pituitary binds to GHRH receptors, and thereby stimulates the secretion of natural Growth hormone. The end results in which MOD GRF (1-29) participates are the final results mediated by Growth hormone activity in the body and include proliferation & differentiation of chondrocytes (cartilage cells) resulting in bone growth in childhood; cell growth and regeneration in the whole body; stimulation of amino acid uptake and protein synthesis in muscle and other tissues; important effects on protein, lipid, and carbohydrate metabolism; or roles in cognition, neurogenesis, and neuronal survival.