Pinealon – 100 mg

 Pinealon – 100 mg Product Information

Pinealon is a short peptide consisting of just three amino acids. It is one of a handful of synthetic peptides referred to as peptide bioregulators for their ability to interact directly with DNA to alter gene expression levels. Pinealon has been linked to behavior modification and is thought to help protect a number of cell types, including neurons, against the effects of hypoxia. By direct effect on the pineal gland, pinealon may reduce problems with drug metabolism, circadian rhythm disorders, memory, learning, and more.

Unlike most peptides, pinealon does not appear to bind to cell surface or cytoplasmic receptors. This has led scientists to wonder how the short peptide can have any effect. In the past, it was suggested that pinealon may be small enough to cross lipid bilayers (e.g. the cell membrane, nuclear membrane) and may therefore be able to interact directly with DNA. Testing in cell cultures (HeLa cells) indicates that pinealon directly penetrates the cell membrane as well as the nuclear membrane to interact with P-21 – 50mgDNA.

This makes pinealon a regulator of gene expression and explains the peptide’s myriad effects that cannot be explained by receptor interactions.

Anti-Aging

Pinealon may have anti-aging effects in the central nervous system. Research from Russia indicates that pinealon and a similar peptide, vesugen, are anabolic in the brain and can actually slow the rate of aging when calculated using biological age indicators

Pinealon is active in cells outside of the central nervous system as well. Research shows that the peptide also has effects on muscle cells where it alters the expression of irisin.

Irisin is important to protecting muscle cells during exercise, promotes fat burning, and is thought to induce telomere elongation as well. By increasing the lifespan of irisin, pinealon boosts telomere protection and helps to fight off the effects of aging and oxidative stress. In fact, plasma irisin levels are directly linked to telomere length in healthy adults and levels of the enzyme have been directly linked to calorie restriction, one of the few activities known beyond doubt to prolong life and improve overall fitness. Interestingly, there is evidence that irisin is active outside of muscle cells and that pinealon may therefore have anti-aging effects that are broadly distributed throughout the body, including the brain.

Label Information

Synonyms: glutamyl aspartyl arginine

Molecolar Formula: C15H26N6O8

Chain: Glu-Asp-Arg

Peptide Purity: Greater than 98%.

TFA Free Peptide

Shipping Conditions: Ambient temperature only.

Storage: Lyophilised peptide must be stored at -20°C and peptide solution at 4°C. Before mixing, keep between -18 and -20°C. Use within 24 months. Once reconstituted use within 20 days. Do not freeze once reconstituted.